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A high-throughput mutational scan of an intrinsically disordered acidic transcriptional activation domain
Transcriptional activation domains are essential for gene regulation but their intrinsic disorder and low primary sequence conservation have made it difficult to identify the amino acid composition features that underlie their activity. Here, we describe a rational mutagenesis scheme that deconvolve...
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| Publicat a: | Cell Syst |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5920710/ https://ncbi.nlm.nih.gov/pubmed/29525204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.01.015 |
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