Control of transcriptional activity by design of charge patterning in the intrinsically disordered RAM region of the Notch receptor

Intrinsically disordered regions (IDRs) play important roles in proteins that regulate gene expression. A prominent example is the intracellular domain of the Notch receptor (NICD), which regulates the transcription of Notch-responsive genes. The NICD sequence includes an intrinsically disordered RA...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Sherry, Kathryn P., Das, Rahul K., Pappu, Rohit V., Barrick, Doug
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676888/
https://ncbi.nlm.nih.gov/pubmed/29078291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706083114
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