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Inhibition of UDP‐glucuronosyltransferase by Aglycons of Natural Glucuronides in Kampo Medicines Using SN‐38 as a Substrate
7‐Ethyl‐10‐[4‐(piperidino)‐1‐piperidino]carbonyloxycamptothecin (CPT‐11), a potent anticancer agent for lung and gynecological cancers, is metabolized in vivo to the active compound, 7‐ethyI‐10‐hydroxycamptothecin (SN‐38), which is subsequently conjugated to SN‐38‐glucuronide by UDP‐glucuronosyltran...
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Publicado no: | Jpn J Cancer Res |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Blackwell Publishing Ltd
1995
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5920600/ https://ncbi.nlm.nih.gov/pubmed/7493919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb03011.x |
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