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Inhibition of UDP‐glucuronosyltransferase by Aglycons of Natural Glucuronides in Kampo Medicines Using SN‐38 as a Substrate

7‐Ethyl‐10‐[4‐(piperidino)‐1‐piperidino]carbonyloxycamptothecin (CPT‐11), a potent anticancer agent for lung and gynecological cancers, is metabolized in vivo to the active compound, 7‐ethyI‐10‐hydroxycamptothecin (SN‐38), which is subsequently conjugated to SN‐38‐glucuronide by UDP‐glucuronosyltran...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Yokoi, Tsuyoshi, Narita, Mikako, Nagai, Eiichi, Hagiwara, Hisao, Aburada, Masaki, Kamataki, Tetsuya
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920600/
https://ncbi.nlm.nih.gov/pubmed/7493919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1995.tb03011.x
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