Identification of the allosteric P2X(7) receptor antagonist [(11)C]SMW139 as a PET tracer of microglial activation

The P2X(7) receptor plays a significant role in microglial activation, and as a potential drug target, the P2X(7) receptor is also an interesting target in positron emission tomography. The current study aimed at the development and evaluation of a potent tracer targeting the P2X(7) receptor, to whi...

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Publicado no:Sci Rep
Main Authors: Janssen, Bieneke, Vugts, Danielle J., Wilkinson, Shane M., Ory, Dieter, Chalon, Sylvie, Hoozemans, Jeroen J. M., Schuit, Robert C., Beaino, Wissam, Kooijman, Esther J. M., van den Hoek, Johan, Chishty, Mansoor, Doméné, Aurélie, Van der Perren, Anke, Villa, Alessandro, Maggi, Adriana, Molenaar, Ger T., Funke, Uta, Shevchenko, Rostislav V., Baekelandt, Veerle, Bormans, Guy, Lammertsma, Adriaan A., Kassiou, Michael, Windhorst, Albert D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5920098/
https://ncbi.nlm.nih.gov/pubmed/29700413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24814-0
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