The P2X(7) receptor tracer [(11)C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study

PURPOSE: The novel PET tracer [(11)C]SMW139 binds with high affinity to the P2X(7) receptor, which is expressed on pro-inflammatory microglia. The purposes of this first in-man study were to characterise pharmacokinetics of [(11)C]SMW139 in patients with active relapsing remitting multiple sclerosis...

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Bibliografske podrobnosti
izdano v:Eur J Nucl Med Mol Imaging
Main Authors: Hagens, Marloes H. J., Golla, Sandeep S. V., Janssen, Bieneke, Vugts, Danielle J., Beaino, Wissam, Windhorst, Albert D., O’Brien-Brown, James, Kassiou, Michael, Schuit, Robert C., Schwarte, Lothar A., de Vries, Helga E., Killestein, Joep, Barkhof, Frederik, van Berckel, Bart N. M., Lammertsma, Adriaan A.
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2019
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974509/
https://ncbi.nlm.nih.gov/pubmed/31705174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-019-04550-x
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