HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation

Adverse birth outcomes are common in HIV-positive pregnant women receiving combination antiretroviral therapy (cART), especially when cART is initiated in early pregnancy. The mechanisms remain poorly understood. Using a mouse model we demonstrate that protease inhibitor based-cART exposure beginnin...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mohammadi, Hakimeh, Papp, Eszter, Cahill, Lindsay, Rennie, Monique, Banko, Nicole, Pinnaduwage, Lakmini, Lee, Janice, Kibschull, Mark, Dunk, Caroline, Sled, John G., Serghides, Lena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919912/
https://ncbi.nlm.nih.gov/pubmed/29700323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24680-w
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