A Phase I/II Study for Dose-finding, and to Investigate the Safety, Pharmacokinetics and Preliminary Efficacy of NK012, an SN-38-Incorporating Macromolecular Polymeric Micelle, in Patients with Multiple Myeloma

OBJECTIVE: Multiple myeloma (MM) is the second most common hematological cancer. An attempt to treat MM using a topoisomerase I inhibitor was made based on our previous non-clinical studies suggesting the usefulness of an SN-38 derivative. Our aim was to conduct a phase I/II study of NK012, a micell...

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Dettagli Bibliografici
Pubblicato in:Intern Med
Autori principali: Ri, Masaki, Suzuki, Kenshi, Iida, Shinsuke, Hatake, Kiyohiko, Chou, Takaaki, Taniwaki, Masafumi, Watanabe, Noriko, Tsukamoto, Tetsuji
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Japanese Society of Internal Medicine 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919849/
https://ncbi.nlm.nih.gov/pubmed/29225263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2169/internalmedicine.9567-17
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