Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes

Major histocompatibility (MHC) class II molecules are strongly associated with many autoimmune disorders. In type 1 diabetes (T1D), the DQ8 molecule is common, confers significant disease risk, and is involved in disease pathogenesis. We hypothesized that blocking DQ8 antigen presentation would prov...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ostrov, David A., Alkanani, Aimon, McDaniel, Kristen A., Case, Stephanie, Baschal, Erin E., Pyle, Laura, Ellis, Sam, Pöllinger, Bernadette, Seidl, Katherine J., Shah, Viral N., Garg, Satish K., Atkinson, Mark A., Gottlieb, Peter A., Michels, Aaron W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919818/
https://ncbi.nlm.nih.gov/pubmed/29438107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97739
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