Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes

Major histocompatibility (MHC) class II molecules are strongly associated with many autoimmune disorders. In type 1 diabetes (T1D), the DQ8 molecule is common, confers significant disease risk, and is involved in disease pathogenesis. We hypothesized that blocking DQ8 antigen presentation would prov...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Ostrov, David A., Alkanani, Aimon, McDaniel, Kristen A., Case, Stephanie, Baschal, Erin E., Pyle, Laura, Ellis, Sam, Pöllinger, Bernadette, Seidl, Katherine J., Shah, Viral N., Garg, Satish K., Atkinson, Mark A., Gottlieb, Peter A., Michels, Aaron W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919818/
https://ncbi.nlm.nih.gov/pubmed/29438107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI97739
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