RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome

Receptor interacting protein kinase 1 (RIPK1) has important kinase-dependent and kinase-independent scaffolding functions that activate or prevent apoptosis or necroptosis in a cell context–dependent manner. The kinase activity of RIPK1 mediates hypothermia and lethality in a mouse model of TNF-indu...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Zelic, Matija, Roderick, Justine E., O’Donnell, Joanne A., Lehman, Jesse, Lim, Sung Eun, Janardhan, Harish P., Trivedi, Chinmay M., Pasparakis, Manolis, Kelliher, Michelle A.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919800/
https://ncbi.nlm.nih.gov/pubmed/29664014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96147
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