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Preclinical evaluation of a novel engineered recombinant human anti-CD44v6 antibody for potential use in radio-immunotherapy

CD44v6 is overexpressed in a variety of cancers, rendering it a promising target for radio-immunotherapy (RIT). In this study, we have characterized a novel engineered recombinant monoclonal anti-CD44v6 antibody, AbN44v6, and assessed its potential for use in RIT using either (177)Lu or (131)I as th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Int J Oncol
Hauptverfasser: Mortensen, Anja C., Spiegelberg, Diana, Haylock, Anna-Karin, Lundqvist, Hans, Nestor, Marika
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919712/
https://ncbi.nlm.nih.gov/pubmed/29658563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2018.4364
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