Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein

Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer’s disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here, we used hiPSC-derived neurons to test a compound that...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Young, Jessica E., Fong, Lauren K., Frankowski, Harald, Petsko, Gregory A., Small, Scott A., Goldstein, Lawrence S.B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919412/
https://ncbi.nlm.nih.gov/pubmed/29503090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.01.031
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