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Differential Alterations of Dihydrofolate Reductase Gene in Human Leukemia Cell Lines Made Resistant to Various Folate Analogues
In order to clarify a molecular mechanism of folate resistance in leukemia cells, we studied alterations of the dihydrofolate reductase (DHFR) gene in a human leukemia cell line, MOLT‐3, and its sublines made resistant to methotrexate (MTX), trimetrexate (TMQ) and N(10)‐propargyl‐5,8‐dideazafolic ac...
שמור ב:
| הוצא לאור ב: | Jpn J Cancer Res |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Blackwell Publishing Ltd
1993
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5919023/ https://ncbi.nlm.nih.gov/pubmed/8449831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1993.tb02776.x |
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