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Population-based statistical inference for temporal sequence of somatic mutations in cancer genomes

BACKGROUND: It is well recognized that accumulation of somatic mutations in cancer genomes plays a role in carcinogenesis; however, the temporal sequence and evolutionary relationship of somatic mutations remain largely unknown. METHODS: In this study, we built a population-based statistical framewo...

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Detalhes bibliográficos
Publicado no:BMC Med Genomics
Main Authors: Rhee, Je-Keun, Kim, Tae-Min
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918460/
https://ncbi.nlm.nih.gov/pubmed/29697365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-018-0352-z
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