Passage-dependent accumulation of somatic mutations in mesenchymal stromal cells during in vitro culture revealed by whole genome sequencing

Human mesenchymal stromal cells (MSCs) have served as a major cellular resource for cell-based immunomodulatory and regenerative therapies. However, genomic instability may accumulate during ex vivo expansion of MSCs, thereby increasing the potential of malignant transformation. Here, we performed w...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kim, Myungshin, Rhee, Je-Keun, Choi, Hayoung, Kwon, Ahlm, Kim, Jiyeon, Lee, Gun Dong, Jekarl, Dong Wook, Lee, Seungok, Kim, Yonggoo, Kim, Tae-Min
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674020/
https://ncbi.nlm.nih.gov/pubmed/29109420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15155-5
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