Bispecific Antibody‐directed Antitumor Activity of Human CD4(+) Helper/Killer T Cells Induced by Anti–CD3 Monoclonal Antibody plus Interleukin 2

Freshly isolated human CD4(+) T cells can not respond to recombinant interlenkin 2 (rIL–2) because of their lack of p75 IL–2 receptor expression. However, we succeeded In inducing a marked proliferation of purified CD4(+) T cells by activation with rIL–2 plus anti–CD3 monoclonal antibody (mAb) cross...

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Bibliographic Details
Published in:Jpn J Cancer Res
Main Authors: Nishimura, Takashi, Nakamura, Yoshihiko, Takeuchi, Yasuhiro, Gao, Xiuhua, Tokuda, Yutaka, Okumura, Ko, Sonoko, Sonoko
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 1991
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918327/
https://ncbi.nlm.nih.gov/pubmed/1836455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1991.tb01782.x
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