Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus

The earliest autoantibodies in lupus are directed against the RNA binding autoantigen Ro60, but the triggers against this evolutionarily conserved antigen remain elusive. We identified Ro60 orthologs in a subset of human skin, oral, and gut commensal bacterial species and confirmed the presence of t...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Greiling, Teri M., Dehner, Carina, Chen, Xinguo, Hughes, Kevin, Iñiguez, Alonso J., Boccitto, Marco, Ruiz, Daniel Zegarra, Renfroe, Stephen C., Vieira, Silvio M., Ruff, William E., Sim, Soyeong, Kriegel, Christina, Glanternik, Julia, Chen, Xindi, Girardi, Michael, Degnan, Patrick, Costenbader, Karen H., Goodman, Andrew L., Wolin, Sandra L., Kriegel, Martin A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918293/
https://ncbi.nlm.nih.gov/pubmed/29593104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan2306
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