Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus

The earliest autoantibodies in lupus are directed against the RNA binding autoantigen Ro60, but the triggers against this evolutionarily conserved antigen remain elusive. We identified Ro60 orthologs in a subset of human skin, oral, and gut commensal bacterial species and confirmed the presence of t...

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Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Greiling, Teri M., Dehner, Carina, Chen, Xinguo, Hughes, Kevin, Iñiguez, Alonso J., Boccitto, Marco, Ruiz, Daniel Zegarra, Renfroe, Stephen C., Vieira, Silvio M., Ruff, William E., Sim, Soyeong, Kriegel, Christina, Glanternik, Julia, Chen, Xindi, Girardi, Michael, Degnan, Patrick, Costenbader, Karen H., Goodman, Andrew L., Wolin, Sandra L., Kriegel, Martin A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918293/
https://ncbi.nlm.nih.gov/pubmed/29593104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan2306
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