Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus

The earliest autoantibodies in lupus are directed against the RNA binding autoantigen Ro60, but the triggers against this evolutionarily conserved antigen remain elusive. We identified Ro60 orthologs in a subset of human skin, oral, and gut commensal bacterial species and confirmed the presence of t...

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Библиографические подробности
Опубликовано в: :Sci Transl Med
Главные авторы: Greiling, Teri M., Dehner, Carina, Chen, Xinguo, Hughes, Kevin, Iñiguez, Alonso J., Boccitto, Marco, Ruiz, Daniel Zegarra, Renfroe, Stephen C., Vieira, Silvio M., Ruff, William E., Sim, Soyeong, Kriegel, Christina, Glanternik, Julia, Chen, Xindi, Girardi, Michael, Degnan, Patrick, Costenbader, Karen H., Goodman, Andrew L., Wolin, Sandra L., Kriegel, Martin A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918293/
https://ncbi.nlm.nih.gov/pubmed/29593104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan2306
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