Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8(+) T cells

CD8+ T cells play an important role in controlling Flavivirus infection, including Zika virus (ZIKV). Here, we have identified 25 HLA-B*0702-restricted epitopes and 1 HLA-A*0101-restricted epitope using interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) and intracellular cytokine staining (ICS) i...

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發表在:Nat Microbiol
Main Authors: Wen, Jinsheng, Tang, William Weihao, Sheets, Nicholas, Ellison, Julia, Sette, Alessandro, Kim, Kenneth, Shresta, Sujan
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5918137/
https://ncbi.nlm.nih.gov/pubmed/28288094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmicrobiol.2017.36
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