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Detection of Multidrug Resistance (MDR1) Gene RNA Expression in Human Tumors by a Sensitive Ribonuclease Protection Assay

The human MDR1 gene encoding P‐glycoprotein, an energy‐dependent drug‐efflux pump, was initially isolated from a multidrug‐resistant KB carcinoma cell. When a 3 kb genomlc sequence isolated from normal human tissue including the major downstream promoter and the first and second exons of the MDR1 ge...

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Publicat a:Jpn J Cancer Res
Autors principals: Ueda, Kazumitsu, Yamano, Yoshiaki, Kioka, Noriyuki, Kakehi, Yoshiyuki, Yoshida, Osamu, Gottesman, Michael M., Pastan, Ira, Komano, Tohru
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 1989
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5917905/
https://ncbi.nlm.nih.gov/pubmed/2481665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1989.tb02269.x
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