Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation

BACKGROUND: Tumor necrosis factor (TNF) is associated with several neurodegenerative disorders including multiple sclerosis (MS). Although TNF-targeted therapies have been largely unsuccessful in MS, recent preclinical data suggests selective soluble TNF inhibition can promote remyelination. This ha...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Valentin-Torres, Alice, Savarin, Carine, Barnett, Joslyn, Bergmann, Cornelia C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916830/
https://ncbi.nlm.nih.gov/pubmed/29690885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1164-y
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