Association Between Thiopurine S-Methyltransferase (TPMT) Genetic Variants and Infection in Pediatric Heart Transplant Recipients Treated With Azathioprine: A Multi-Institutional Analysis

OBJECTIVES: Bone marrow suppression is a common adverse effect of the immunosuppressive drug azathioprine. Polymorphisms in the gene encoding thiopurine S-methyltransferase (TPMT) can alter the metabolism of azathioprine, resulting in marrow toxicity and life-threatening infection. In a multicenter...

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Detalhes bibliográficos
Publicado no:J Pediatr Pharmacol Ther
Main Authors: Green, Dionna J., Duong, Son Q., Burckart, Gilbert J., Sissung, Tristan, Price, Douglas K., Figg, William D., Brooks, Maria M., Chinnock, Richard, Canter, Charles, Addonizio, Linda, Bernstein, Daniel, Naftel, David C., Zeevi, Adriana, Kirklin, James K., Webber, Steven A., Feingold, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: Pediatric Pharmacy Advocacy Group 2018
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916437/
https://ncbi.nlm.nih.gov/pubmed/29720911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5863/1551-6776-23.2.106
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