CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development

CHD7, an ATP-dependent chromatin remodeler, is disrupted in CHARGE syndrome, an autosomal dominant disorder characterized by variably penetrant abnormalities in craniofacial, cardiac, and nervous system tissues. The inner ear is uniquely sensitive to CHD7 levels and is the most commonly affected org...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Yao, Hui, Hill, Sophie F., Skidmore, Jennifer M., Sperry, Ethan D., Swiderski, Donald L., Sanchez, Gilson J., Bartels, Cynthia F., Raphael, Yehoash, Scacheri, Peter C., Iwase, Shigeki, Martin, Donna M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916250/
https://ncbi.nlm.nih.gov/pubmed/29467333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97440
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