CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development

CHD7, an ATP-dependent chromatin remodeler, is disrupted in CHARGE syndrome, an autosomal dominant disorder characterized by variably penetrant abnormalities in craniofacial, cardiac, and nervous system tissues. The inner ear is uniquely sensitive to CHD7 levels and is the most commonly affected org...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Yao, Hui, Hill, Sophie F., Skidmore, Jennifer M., Sperry, Ethan D., Swiderski, Donald L., Sanchez, Gilson J., Bartels, Cynthia F., Raphael, Yehoash, Scacheri, Peter C., Iwase, Shigeki, Martin, Donna M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916250/
https://ncbi.nlm.nih.gov/pubmed/29467333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97440
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