Mature middle and inner ears express Chd7 and exhibit distinctive pathologies in a mouse model of CHARGE syndrome

Heterozygous mutations in the gene encoding chromodomain-DNA-binding-protein 7 (CHD7) cause CHARGE syndrome, a multiple anomaly condition which includes vestibular dysfunction and hearing loss. Mice with heterozygous Chd7 mutations exhibit semicircular canal dysgenesis and abnormal inner ear neuroge...

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Detalhes bibliográficos
Main Authors: Hurd, Elizabeth A., Adams, Meredith E., Layman, Wanda S., Swiderski, Donald L., Beyer, Lisa A., Halsey, Karin E., Benson, Jennifer M., Gong, Tzy-Wen, Dolan, David F., Raphael, Yehoash, Martin, Donna M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230679/
https://ncbi.nlm.nih.gov/pubmed/21875659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heares.2011.08.005
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