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Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor
Tumor metastasis is responsible for ~90% of all cancer deaths. One of the key steps of tumor metastasis is tumor cell migration and invasion. Filopodia are cell surface extensions that are critical for tumor cell migration. Fascin protein is the main actin-bundling protein in filopodia. Small-molecu...
Tallennettuna:
| Julkaisussa: | J Mol Biol |
|---|---|
| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5916032/ https://ncbi.nlm.nih.gov/pubmed/29573988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.03.009 |
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