Metabolism and hydrophilicity of the polarised ‘Janus face’ all-cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery

The metabolism and polarity of the all-cis tetra-fluorocyclohexane motif is explored in the context of its potential as a motif for inclusion in drug discovery programmes. Biotransformations of phenyl all-cis tetra-, tri- and di- fluoro cyclohexanes with the human metabolism model organism Cunningha...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Rodil, Andrea, Bosisio, Stefano, Ayoup, Mohammed Salah, Quinn, Laura, Cordes, David B., Slawin, Alexandra M. Z., Murphy, Cormac D., Michel, Julien, O'Hagan, David
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916015/
https://ncbi.nlm.nih.gov/pubmed/29732086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc00299a
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