M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion

Uncovering the cellular and molecular mechanisms by which hematopoietic stem cell (HSC) self-renewal is regulated can lead to the development of new strategies for promoting ex vivo HSC expansion. Here, we report the discovery that alternative (M2)-polarized macrophages (M2-MΦs) promote, but classic...

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Détails bibliographiques
Publié dans:Blood Adv
Auteurs principaux: Luo, Yi, Shao, Lijian, Chang, Jianhui, Feng, Wei, Liu, Y. Lucy, Cottler-Fox, Michele H., Emanuel, Peter D., Hauer-Jensen, Martin, Bernstein, Irwin D., Liu, Lingbo, Chen, Xing, Zhou, Jianfeng, Murray, Peter J., Zhou, Daohong
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2018
Sujets:
Hematopoiesis and Stem Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916005/
https://ncbi.nlm.nih.gov/pubmed/29666049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018015685
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