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Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence

BACKGROUND: The mTOR is an important regulator of HSCs self-renewal and its overactivation contributes to HSCs premature exhaustion in part via induction of HSCs senescence. Inhibition of mTOR with rapamycin has the potential to promote long term hematopoiesis of ex vivo expanded HSCs to facilitate...

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Bibliographic Details
Main Authors: Luo, Yi, Li, Lei, Zou, Ping, Wang, Jie, Shao, Lijian, Zhou, Daohong, Liu, Lingbo
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877183/
https://ncbi.nlm.nih.gov/pubmed/24092377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e3182a7fcf8
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