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In vitro biosynthetic studies of bottromycin expand the enzymatic capabilities of the YcaO superfamily

The bottromycins belong to the ribosomally synthesized and posttranslationally modified peptide (RiPP) family of natural products. Bottromycins exhibit unique structural features, including a hallmark macrolactamidine ring and thiazole heterocycle for which divergent members of the YcaO superfamily...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Schwalen, Christopher J., Hudson, Graham A., Kosol, Simone, Mahanta, Nilkamal, Challis, Gregory L., Mitchell, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915351/
https://ncbi.nlm.nih.gov/pubmed/29200283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09899
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