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Enzymatic reconstitution and biosynthetic investigation of the lasso peptide Fusilassin

Lasso peptides are a class of ribosomally synthesized natural product which possess a unique lariat knot conformation. The low entropy “threaded” conformation endows lasso peptides with considerable resistance to heat and proteolytic degradation, which are attractive properties for the development o...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: DiCaprio, Adam J., Firouzbakht, Arash, Hudson, Graham A., Mitchell, Douglas A.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7368380/
https://ncbi.nlm.nih.gov/pubmed/30589265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b09928
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