ONC201 kills breast cancer cells in vitro by targeting mitochondria

We report a novel mechanism of action of ONC201 as a mitochondria-targeting drug in cancer cells. ONC201 was originally identified as a small molecule that induces transcription of TNF-related apoptosis-inducing ligand (TRAIL) and subsequently kills cancer cells by activating TRAIL death receptors....

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Greer, Yoshimi Endo, Porat-Shliom, Natalie, Nagashima, Kunio, Stuelten, Christina, Crooks, Dan, Koparde, Vishal N., Gilbert, Samuel F., Islam, Celia, Ubaldini, Ashley, Ji, Yun, Gattinoni, Luca, Soheilian, Ferri, Wang, Xiantao, Hafner, Markus, Shetty, Jyoti, Tran, Bao, Jailwala, Parthav, Cam, Maggie, Lang, Martin, Voeller, Donna, Reinhold, William C., Rajapakse, Vinodh, Pommier, Yves, Weigert, Roberto, Linehan, W. Marston, Lipkowitz, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915085/
https://ncbi.nlm.nih.gov/pubmed/29719618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24862
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