ONC201 kills breast cancer cells in vitro by targeting mitochondria

We report a novel mechanism of action of ONC201 as a mitochondria-targeting drug in cancer cells. ONC201 was originally identified as a small molecule that induces transcription of TNF-related apoptosis-inducing ligand (TRAIL) and subsequently kills cancer cells by activating TRAIL death receptors....

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Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Greer, Yoshimi Endo, Porat-Shliom, Natalie, Nagashima, Kunio, Stuelten, Christina, Crooks, Dan, Koparde, Vishal N., Gilbert, Samuel F., Islam, Celia, Ubaldini, Ashley, Ji, Yun, Gattinoni, Luca, Soheilian, Ferri, Wang, Xiantao, Hafner, Markus, Shetty, Jyoti, Tran, Bao, Jailwala, Parthav, Cam, Maggie, Lang, Martin, Voeller, Donna, Reinhold, William C., Rajapakse, Vinodh, Pommier, Yves, Weigert, Roberto, Linehan, W. Marston, Lipkowitz, Stanley
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2018
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915085/
https://ncbi.nlm.nih.gov/pubmed/29719618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24862
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