ONC201 kills breast cancer cells in vitro by targeting mitochondria

We report a novel mechanism of action of ONC201 as a mitochondria-targeting drug in cancer cells. ONC201 was originally identified as a small molecule that induces transcription of TNF-related apoptosis-inducing ligand (TRAIL) and subsequently kills cancer cells by activating TRAIL death receptors....

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Pubblicato in:Oncotarget
Autori principali: Greer, Yoshimi Endo, Porat-Shliom, Natalie, Nagashima, Kunio, Stuelten, Christina, Crooks, Dan, Koparde, Vishal N., Gilbert, Samuel F., Islam, Celia, Ubaldini, Ashley, Ji, Yun, Gattinoni, Luca, Soheilian, Ferri, Wang, Xiantao, Hafner, Markus, Shetty, Jyoti, Tran, Bao, Jailwala, Parthav, Cam, Maggie, Lang, Martin, Voeller, Donna, Reinhold, William C., Rajapakse, Vinodh, Pommier, Yves, Weigert, Roberto, Linehan, W. Marston, Lipkowitz, Stanley
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915085/
https://ncbi.nlm.nih.gov/pubmed/29719618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24862
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