Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells

HuR plays an important role in tumor cell survival mainly through posttranscriptional upregulation of prominent anti-apoptotic genes. In addition, HuR can inhibit the translation of pro-apoptotic factors as we could previously report for caspase-2. Here, we investigated the mechanisms of caspase-2 s...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Badawi, Amel, Biyanee, Abhiruchi, Nasrullah, Usman, Winslow, Sofia, Schmid, Tobias, Pfeilschifter, Josef, Eberhardt, Wolfgang
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915078/
https://ncbi.nlm.nih.gov/pubmed/29719611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24840
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