Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L

Caspase-2 represents the most conserved member of the caspase family, which exhibits features of both initiator and effector caspases. Using ribonucleoprotein (RNP)-immunoprecipitation assay, we identified the proapoptotic caspase-2L encoding mRNA as a novel target of the ubiquitous RNA-binding prot...

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Detalhes bibliográficos
Main Authors: Winkler, C, Doller, A, Imre, G, Badawi, A, Schmid, T, Schulz, S, Steinmeyer, N, Pfeilschifter, J, Rajalingam, K, Eberhardt, W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123073/
https://ncbi.nlm.nih.gov/pubmed/25010987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.279
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