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Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase Cδ Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR

Stabilization of mRNA by the ubiquitous RNA binding protein human antigen R (HuR), a member of the embryonic lethal abnormal vision (ELAV) protein family, requires canonical binding to AU-rich element (ARE)-bearing target mRNA and export of nuclear HuR-mRNA complexes to the cytoplasm. In human mesan...

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Autors principals: Doller, Anke, Schlepckow, Kai, Schwalbe, Harald, Pfeilschifter, Josef, Eberhardt, Wolfgang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832487/
https://ncbi.nlm.nih.gov/pubmed/20086103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01373-09
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