Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA

The mRNA stabilizing factor HuR is involved in the posttranscriptional regulation of many genes, including that coding for cyclooxygenase 2 (COX-2). Employing RNA interference technology and actinomycin D experiments, we demonstrate that in human mesangial cells (hMC) the amplification of cytokine-i...

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Detalhes bibliográficos
Main Authors: Doller, Anke, Akool, El-Sayed, Huwiler, Andrea, Müller, Roswitha, Radeke, Heinfried H., Pfeilschifter, Josef, Eberhardt, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293108/
https://ncbi.nlm.nih.gov/pubmed/18285462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01530-07
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