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Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase Cδ Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA

The mRNA stabilizing factor HuR is involved in the posttranscriptional regulation of many genes, including that coding for cyclooxygenase 2 (COX-2). Employing RNA interference technology and actinomycin D experiments, we demonstrate that in human mesangial cells (hMC) the amplification of cytokine-i...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Doller, Anke, Akool, El-Sayed, Huwiler, Andrea, Müller, Roswitha, Radeke, Heinfried H., Pfeilschifter, Josef, Eberhardt, Wolfgang
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology (ASM) 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293108/
https://ncbi.nlm.nih.gov/pubmed/18285462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01530-07
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