Whole exome sequencing identifies mTOR and KEAP1 as potential targets for radiosensitization of HNSCC cells refractory to EGFR and β1 integrin inhibition

Intrinsic and acquired resistances are major obstacles in cancer therapy. Genetic characterization is commonly used to identify predictive or prognostic biomarker signatures and potential cancer targets in samples from therapy-naïve patients. By far less common are such investigations to identify sp...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Klapproth, Erik, Dickreuter, Ellen, Zakrzewski, Falk, Seifert, Michael, Petzold, Andreas, Dahl, Andreas, Schröck, Evelin, Klink, Barbara, Cordes, Nils
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915060/
https://ncbi.nlm.nih.gov/pubmed/29719593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24266
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