Whole exome sequencing identifies mTOR and KEAP1 as potential targets for radiosensitization of HNSCC cells refractory to EGFR and β1 integrin inhibition

Intrinsic and acquired resistances are major obstacles in cancer therapy. Genetic characterization is commonly used to identify predictive or prognostic biomarker signatures and potential cancer targets in samples from therapy-naïve patients. By far less common are such investigations to identify sp...

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Pubblicato in:Oncotarget
Autori principali: Klapproth, Erik, Dickreuter, Ellen, Zakrzewski, Falk, Seifert, Michael, Petzold, Andreas, Dahl, Andreas, Schröck, Evelin, Klink, Barbara, Cordes, Nils
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915060/
https://ncbi.nlm.nih.gov/pubmed/29719593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24266
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