Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease

Current therapeutic options for cryptococcal meningitis are limited by toxicity, global supply, and emergence of resistance. There is an urgent need to develop additional antifungal agents that are fungicidal within the central nervous system and preferably orally bioavailable. The benzimidazoles ha...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Nixon, Gemma L., McEntee, Laura, Johnson, Adam, Farrington, Nicola, Whalley, Sarah, Livermore, Joanne, Natal, Cristien, Washbourn, Gina, Bibby, Jaclyn, Berry, Neil, Lestner, Jodi, Truong, Megan, Owen, Andrew, Lalloo, David, Charles, Ian, Hope, William
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913986/
https://ncbi.nlm.nih.gov/pubmed/29311092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01909-17
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