Repurposing and Reformulation of the Antiparasitic Agent Flubendazole for Treatment of Cryptococcal Meningoencephalitis, a Neglected Fungal Disease

Current therapeutic options for cryptococcal meningitis are limited by toxicity, global supply, and emergence of resistance. There is an urgent need to develop additional antifungal agents that are fungicidal within the central nervous system and preferably orally bioavailable. The benzimidazoles ha...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Nixon, Gemma L., McEntee, Laura, Johnson, Adam, Farrington, Nicola, Whalley, Sarah, Livermore, Joanne, Natal, Cristien, Washbourn, Gina, Bibby, Jaclyn, Berry, Neil, Lestner, Jodi, Truong, Megan, Owen, Andrew, Lalloo, David, Charles, Ian, Hope, William
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913986/
https://ncbi.nlm.nih.gov/pubmed/29311092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01909-17
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