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Evolution of the Pseudomonas aeruginosa Aminoglycoside Mutational Resistome In Vitro and in the Cystic Fibrosis Setting

Inhaled administration of high doses of aminoglycosides is a key maintenance treatment of Pseudomonas aeruginosa chronic respiratory infections in cystic fibrosis (CF). We analyzed the dynamics and mechanisms of stepwise high-level tobramycin resistance development in vitro and compared the results...

詳細記述

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: López-Causapé, Carla, Rubio, Rosa, Cabot, Gabriel, Oliver, Antonio
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913951/
https://ncbi.nlm.nih.gov/pubmed/29437613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02583-17
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