Evolution of the Pseudomonas aeruginosa Aminoglycoside Mutational Resistome In Vitro and in the Cystic Fibrosis Setting

Inhaled administration of high doses of aminoglycosides is a key maintenance treatment of Pseudomonas aeruginosa chronic respiratory infections in cystic fibrosis (CF). We analyzed the dynamics and mechanisms of stepwise high-level tobramycin resistance development in vitro and compared the results...

Full description

Saved in:
Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: López-Causapé, Carla, Rubio, Rosa, Cabot, Gabriel, Oliver, Antonio
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913951/
https://ncbi.nlm.nih.gov/pubmed/29437613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02583-17
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items