AMINOGLYCOSIDE RESISTANCE OF PSEUDOMONAS AERUGINOSA IN CYSTIC FIBROSIS RESULTS FROM CONVERGENT EVOLUTION IN THE MEXZ GENE

RATIONALE: Aminoglycoside (AG) resistance by Pseudomonas aeruginosa in Cystic Fibrosis is associated with poorer clinical outcomes and is usually due to overexpression of the efflux pump MexXY. MexXY is regulated by mexZ, one of the most commonly mutated genes in CF P. aeruginosa isolates. Little is...

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Bibliografiska uppgifter
I publikationen:Thorax
Huvudupphovsmän: Prickett, Michelle H, Hauser, Alan R, McColley, Susanna A, Cullina, Joanne, Potter, Eileen, Powers, Cathy, Jain, Manu
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497499/
https://ncbi.nlm.nih.gov/pubmed/27325751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2015-208027
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