AMINOGLYCOSIDE RESISTANCE OF PSEUDOMONAS AERUGINOSA IN CYSTIC FIBROSIS RESULTS FROM CONVERGENT EVOLUTION IN THE MEXZ GENE

RATIONALE: Aminoglycoside (AG) resistance by Pseudomonas aeruginosa in Cystic Fibrosis is associated with poorer clinical outcomes and is usually due to overexpression of the efflux pump MexXY. MexXY is regulated by mexZ, one of the most commonly mutated genes in CF P. aeruginosa isolates. Little is...

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Foilsithe in:Thorax
Main Authors: Prickett, Michelle H, Hauser, Alan R, McColley, Susanna A, Cullina, Joanne, Potter, Eileen, Powers, Cathy, Jain, Manu
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497499/
https://ncbi.nlm.nih.gov/pubmed/27325751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2015-208027
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