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Shaping Substrate Selectivity in a Broad-Spectrum Metallo-β-Lactamase
Metallo-β-lactamases (MBLs) are the major group of carbapenemases produced by bacterial pathogens. The design of MBL inhibitors has been limited by, among other issues, incomplete knowledge about how these enzymes modulate substrate recognition. While most MBLs are broad-spectrum enzymes, B2 MBLs ar...
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| Udgivet i: | Antimicrob Agents Chemother |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5913924/ https://ncbi.nlm.nih.gov/pubmed/29358299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02079-17 |
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