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Evolution of Broad Spectrum β-Lactam Resistance in an Engineered Metallo-β-lactamase
The extensive use and misuse of antibiotics during the last seven decades has led to the evolution and global spread of a variety of resistance mechanisms in bacteria. Of high medical importance are β-lactamases, a group of enzymes inactivating β-lactam antibiotics. Metallo-β-lactamases (MBLs) are p...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554903/ https://ncbi.nlm.nih.gov/pubmed/23209299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.430199 |
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