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Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach
[Image: see text] Plant homeodomain (PHD) zinc fingers are histone reader domains that are often associated with human diseases. Despite this, they constitute a poorly targeted class of readers, suggesting low ligandability. Here, we describe a successful fragment-based campaign targeting PHD finger...
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| Publicado no: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2018
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5913730/ https://ncbi.nlm.nih.gov/pubmed/29529862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b01093 |
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