Mapping ligand binding pockets in chloride ClC‐1 channels through an integrated in silico and experimental approach using anthracene‐9‐carboxylic acid and niflumic acid

BACKGROUND AND PURPOSE: Although chloride channels are involved in several physiological processes and acquired diseases, the availability of compounds selectively targeting CLC proteins is limited. ClC‐1 channels are responsible for sarcolemma repolarization after an action potential in skeletal mu...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Altamura, C, Mangiatordi, G F, Nicolotti, O, Sahbani, D, Farinato, A, Leonetti, F, Carratù, M R, Conte, D, Desaphy, J‐F, Imbrici, P
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913395/
https://ncbi.nlm.nih.gov/pubmed/29500929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14192
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