GATA6 phosphorylation by Erk1/2 propels exit from pluripotency and commitment to primitive endoderm

The transcription factor GATA6 and the Fgf/Ras/MAPK signaling pathway are essential for the development of the primitive endoderm (PrE), one of the two lineages derived from the pluripotent inner cell mass (ICM) of mammalian blastocysts. A mutant mouse line in which Gata6-coding exons are replaced w...

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Gepubliceerd in:Dev Biol
Hoofdauteurs: Meng, Yue, Moore, Robert, Tao, Wensi, Smith, Elizabeth R., Tse, Jeffrey D., Caslini, Corrado, Xu, Xiang-Xi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912698/
https://ncbi.nlm.nih.gov/pubmed/29454706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2018.02.007
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