A step-by-step in crystallo guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase

Lytic transglycosylases (LTs) are a class of enzymes important for the recycling and metabolism of peptidoglycan (PG). LTs cleave the β-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and GlcNAc in the PG glycan strand, resulting in the concomitant formation of 1,6-anhydro-N-acetylmuramic...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Williams, Allison H., Wheeler, Richard, Rateau, Lesly, Malosse, Christian, Chamot-Rooke, Julia, Haouz, Ahmed, Taha, Muhamed-Kheir, Boneca, Ivo Gomperts
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912472/
https://ncbi.nlm.nih.gov/pubmed/29483188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001095
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