Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis

Lytic transglycosylases (LT) are enzymes involved in peptidoglycan (PG) remodeling. However, their contribution to cell-wall-modifying complexes and their potential as antimicrobial drug targets remains unclear. Here, we determined a high-resolution structure of the LT, an outer membrane lipoprotein...

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Vydáno v:eLife
Hlavní autoři: Williams, Allison Hillary, Wheeler, Richard, Deghmane, Ala-Eddine, Santecchia, Ignacio, Schaub, Ryan E, Hicham, Samia, Moya Nilges, Maryse, Malosse, Christian, Chamot-Rooke, Julia, Haouz, Ahmed, Dillard, Joseph P, Robins, William P, Taha, Muhamed-Kheir, Gomperts Boneca, Ivo
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Microbiology and Infectious Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083599/
https://ncbi.nlm.nih.gov/pubmed/32022687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51247
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